Role of dipeptidyl peptidase 4 (DPP4) in collagen metabolism and dipeptide homeostasis. University of Antwerp
This project aims to unravel the effects of DPP4 inhibition on collagen and collagen-derived dipeptide metabolism. We willdevelop and validate methods to quantify, in biological matrices, dipeptides resulting from DPP4 mediated cleavage. Next, the effects of DPP4 inhibition on the collagen metabolism and the dipeptide profile will be studied in vitro in fibroblast and osteoblast cultures. The in vivo relevance of our findings will be evaluated ...