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The effect of dosing regimens on the antimalarial efficacy of dihydroartemisinin-piperaquine: a pooled analysis of individual patient data Institute of Tropical Medicine

D'Alessandro
BACKGROUND: Dihydroartemisinin-piperaquine (DP) is increasingly recommended for antimalarial treatment in many endemic countries; however, concerns have been raised over its potential under dosing in young children. We investigated the influence of different dosing schedules on DP's clinical efficacy. METHODS AND FINDINGS: A systematic search of the literature was conducted to identify all studies published between 1960 and February 2013, in ...

The gametocytocidal efficacy of primaquine in malaria asymptomatic carriers treated with dihydroartemisinin-piperaquine in The Gambia (PRINOGAM) Institute of Tropical Medicine University of Antwerp

J. Okebe, T. Bousema, M. Affara, G. DiTanna, A.C. Eziefula, M Jawara, D. Nwakanma, A. Amambua-Ngwa, J.P. Van geertruyden, C. Drakeley, et al.
BACKGROUND: Finding efficacious tools to decrease and interrupt malaria transmission is essential to sustain the gains in malaria control and contain the emergence of artemisinin resistance. Primaquine is effective against Plasmodium falciparum gametocytes and recommended for treatment campaigns in (pre-)elimination settings. Safety concerns preclude its use in endemic African countries with variable proportions of glucose-6-phosphate ...

Mass drug administration with high-dose ivermectin and dihydroartemisinin-piperaquine for malaria elimination in an erea of low transmission with high coverage of malaria control interventions: protocol for the MASSIV cluster randomized clinical trial Institute of Tropical Medicine

Edgard Diniba Dabira, Harouna M. Soumare, Steven W. Lindsay, Bakary Conteh, Fatima Ceesay, John Bradley, Christian Kositz, Henk Broekhuizen, Balla Kandeh, Alexandra E. Fehr, et al.

Background: With a decline in malaria burden, innovative interventions and tools are required to reduce malaria transmission further. Mass drug administration (MDA) of artemisinin-based combination therapy (ACT) has been identified as a potential tool to further reduce malaria transmission, where coverage of vector control interventions is already high. However, the impact is limited in time. Combining an ACT with an endectocide treatment ...

Efficacy of quinine, artemether-lumefantrine and dihydroartemisinin-piperaquine as rescue treatment for uncomplicated malaria in Ugandan children Institute of Tropical Medicine

A Yeka, J. Tibenderana, Jane Achan, Umberto D'Alessandro, A.O. Talisuna
BACKGROUND: The treatment of falciparum malaria poses unique challenges in settings where malaria transmission intensity is high because recurrent infections are common. These could be new infections, recrudescences, or a combination of the two. Though several African countries continue to use quinine as the second line treatment for patients with recurrent infections, there is little information on its efficacy when used for rescue therapy. ...

Safety and efficacy of dihydroartemisinin-piperaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Zambian children Institute of Tropical Medicine

M Nambozi, Jean-Pierre Van Geertruyden, S Hachizovu, M. Chaponda, D Mukwamataba, M. Mulenga, D. Ubben, U D'Alessandro
BACKGROUND: Malaria in Zambia remains a public health and developmental challenge, affecting mostly children under five and pregnant women. In 2002, the first-line treatment for uncomplicated malaria was changed to artemether-lumefantrine (AL) that has proved to be highly efficacious against multidrug resistant Plasmodium falciparum. OBJECTIVE: The study objective was to determine whether dihydroartemisinin-piperaquine (DHA/PQP) had similar ...

Effectiveness and safety of intermittent preventive treatment with dihydroartemisinin-piperaquine or artesunate-amodiaquine for reducing malaria and related morbidities in schoolchildren in Tanzania: a randomised controlled trial University of Antwerp

Geofrey Makenga, Vito Baraka, Filbert Francis, Swabra Nakato, Samwel Gesase, George Mtove, Rashid Madebe, Edna Kyaruzi, Daniel T.R. Minja, John P.A. Lusingu, et al.
Background In high transmission settings, most school-aged children harbour malaria parasites without showing symptoms, often leading to anaemia and possibly impaired psychomotor and cognitive abilities. We aimed to assess the effectiveness and safety of intermittent preventive treatment for malaria in school-aged children (IPTsc) living in highly endemic areas. Methods We did an open-label randomised controlled trial in seven primary schools in ...