Projects
Development and evaluation of particulate formulations for the selective delivery of antigens and immunpotentiators towards dendritic cells. Ghent University
Developing effective vaccins against insidous pathogens such as HIV, Mycobacterium tuberculosis and HCV represents a major challenge and is likely to require the induction of potent T cell mediated immune responses. In this project we aim to develop a particulate carrier allowing the selective delivery of both antigens and immunpotentiators to dendritic cells in order to promote the induction of potent T cell mediated immune responses.
Increasing the immunotherapeutic capacity of human dendritic cells using innate immune signals. University of Antwerp
LNP-DECODE: Deciphering the adjuvants activity of lipid nanoparticle-based mRNA vaccines in primary dendritic cells Ghent University
This project aims to put UGent at the forefront of mRNA-vaccine research by providing in-depth insights in the adjuvant properties of LNP-based mRNA-vaccines. To this end, we will join the expertise of 3 teams working on dendritic cell biology, nucleic acid sensors and lipid nanoparticles respectively.This consortium will form the basis for the development of vaccines against autoimmune diseases.
The role of dendritic cells in extramedullary hematopoiesis and chronic myeloproliferative disorders. Ghent University
We hypothesize that dendritic cells (DCs) have an undiscovered role in hematopoiesis occurring in the spleen, and that absence of a specific subset of DCs can lead to or exacerbate certain forms of leukemia.
Induction of potent broad-HIV-1 suppressive immune responses by dendritic cells loaded with gag mRNA. University of Antwerp
Characterization of circulating dendritic cells (DC) in multiple sclerosis (MS): evaluation of subtypes and functionality. University of Antwerp
Elucidating the role of CD11b+ conventional dendritic cells (cDC2) in the tumor microenvironment and their potential use as tumor vaccine. Vrije Universiteit Brussel
anti-tumor T cells are first activated in vivo is still incompletely ...
Understanding the transcriptome dynamics of migratory mechanisms of dendritic cells and regulatory T-cells in MS using RNA-Seq. Hasselt University
Role of Endoplasmic Retriculum Stress in dendritic cells and immune-mediated lung disesases Ghent University
Dendritic cells play crucial roles in the regulation of immunity and in the pathogenesis of many inflammatory lung diseases. These cells react to exogenous and endogenous danger signals. Lung cells of mice and patients exposed to environmental triggers of lung disease like allergens, cigarette smoke, fine dust particles or microbes often accumulate unfolded proteins in the endoplasmic reticulum (ER), leading to an adaptive unfolded protein ...