Role of the cation channel TRPV4 in the maturation and migration of lung dendritic cells KU Leuven
The mammalian defence responses against foreign agents such as allergens and pathogens are largely based on an orchestrated interaction between detector and effector cells of the immune system. For instance, activation of dendritic cells leads to their maturation and migration to the regional lymph node, where they instruct T cells about the nature of the insult. We have found that mice lacking the calcium-permeable channel TRPV4 fail to ...