Projects
Early event in the interaction of antigens/microorganisms with intestinal epithelial cells and intestinal dendritic cells: development of new oral delivery system Ghent University
This project aims to study early events in the interaction of antigens/microorganisms with epithelial cells and intestinal dendritic cells (DCs). Tolerogenic (ovalbumin), immunogenic (F4 fimbriae, CT and CT-B) as well as the less immunogetic F18 fimbriae will be used as antigens and the pathogenic F4+enterotoxigenic E.coli, F18+verotoxigenic E.coli as well as the non-pathogenic E. coli HB101 and Lactococcus Lactis. A genomic wide approach ...
Early event in the interaction of antigens/microorganisms with intestinal epithelial cells and intestinal dendritic cells: development of new oral delivery system Ghent University
This project aims to study early events in the interaction of antigens/microorganisms with epithelial cells and intestinal dendritic cells (DCs). Tolerogenic (ovalbumin), immunogenic (F4 fimbriae, CT and CT-B) as well as the less immunogetic F18 fimbriae will be used as antigens and the pathogenic F4+enterotoxigenic E.coli, F18+verotoxigenic E.coli as well as the non-pathogenic E. coli HB101 and Lactococcus Lactis. A genomic wide approach ...
Unraveling how ZEB1 expression in conventional type I dendritic cells regulates the presence of other cell types specifically in the spleen and the functional consequences of this regulation. Ghent University
Conventional dendritic cells (cDCs) exist as cDC1s and cDC2s and develop from precursors through the concerted action of distinct transcription factors (TFs). Recently, the ZEB family of TFs have been added to the list of TFs mediating cDC development as we and others, have shown that ZEB2 regulates the decision to become a cDC2. Additionally, our data also suggest that its homolog, ZEB1, is a critical cDC TF, specifically regulating splenic ...
Investigating the link between cell clearance by dendritic cells and cutaneous wound healing Ghent University
The skin is our largest organ and a natural barrier against frequent insults such as physical injury. Wound induced breaches to this barrier need to be restored as quickly as possible. Inability to properly repair skin integrity poses a great risk for infections and strongly impacts the quality of life. A crucial step in wound healing is the removal of apoptotic cells present at the injury site, typically performed by phagocytes as part of an ...
Functional chracterisation of regulatory cell populations:In vitro induction of tolerance using dendritic cells. University of Antwerp
Activation of dendritic cells and natural killer cells by leukemia cells loaded with Toll-like receptor ligand: development of a new generation of leukemia vaccines. University of Antwerp
Effect of innate immune signals on leukemia cells for the stimulation of natural killer cells and T helper type 1-polarizing dendritic cells. University of Antwerp
Manipulation of dendritic cells and regulatory T cells for tolerance induction in autoimmune disease models. KU Leuven
Early events in the interaction of antigens/microorganisms with the intestinal epithelial cells and intestinal dendritic cells : development of new innovative oral delivery system. Ghent University
Vaccination is regarded as the most efficient and cost-effective way to prevent infectious diseases.
Vaccine design nowadays focuses on the implementation of safer recombinant subunit vaccines. However, these recombinant subunit antigens are often poor immunogens and several strategies are currently under investigation to enhance their immunogenicity. The encapsulation of the antigens in biodegradable microparticulate delivery ...