Projects

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Boosting the cross-talk between human dendritic cells and natural killer cells by Toll-like receptor-ligand-loaded leukemia cells for optimal anti-leukemia T cell responses. University of Antwerp

Vigor Van Tendeloo
Vaccine & Infectious Disease Institute (VAXINFECTIO)
Currently, targeting both NK cells and DC for immune-based therapy is advised to improve their cross-talk and exert strong specific anti-tumor T cell responses. Therefore, the rationale of this study is to make AML cells more immunogenic for both DC and NK cells. In this respect, Toll-like receptor (TLR)-ligands were recently identified as important danger signals recognized by both DC and NK cells. Exciting results on the DC and NK cell ...

Early event in the interaction of antigens/microorganisms with intestinal epithelial cells and intestinal dendritic cells: development of new oral delivery system Ghent University

Jean Paul Remon
Department of Pharmaceutics

This project aims to study early events in the interaction of antigens/microorganisms with epithelial cells and intestinal dendritic cells (DCs). Tolerogenic (ovalbumin), immunogenic (F4 fimbriae, CT and CT-B) as well as the less immunogetic F18 fimbriae will be used as antigens and the pathogenic F4+enterotoxigenic E.coli, F18+verotoxigenic E.coli as well as the non-pathogenic E. coli HB101 and Lactococcus Lactis. A genomic wide approach ...

Early event in the interaction of antigens/microorganisms with intestinal epithelial cells and intestinal dendritic cells: development of new oral delivery system Ghent University

Marleen Praet
Department of Medical and Forensic Pathology

This project aims to study early events in the interaction of antigens/microorganisms with epithelial cells and intestinal dendritic cells (DCs). Tolerogenic (ovalbumin), immunogenic (F4 fimbriae, CT and CT-B) as well as the less immunogetic F18 fimbriae will be used as antigens and the pathogenic F4+enterotoxigenic E.coli, F18+verotoxigenic E.coli as well as the non-pathogenic E. coli HB101 and Lactococcus Lactis. A genomic wide approach ...

Functional chracterisation of regulatory cell populations:In vitro induction of tolerance using dendritic cells. University of Antwerp

Nathalie Cools
Vaccine & Infectious Disease Institute (VAXINFECTIO)
In the current project, our aim is to further investigate and exploit the capacity of dendritic cells and regulatory T cells to suppress antigen-specific immune responses. A better understanding of their interactions, as well as the mechanisms involved in the induction of peripheral T cell tolerance will ultimately lead to the development of new therapies for immune-mediated pathologies.

Activation of dendritic cells and natural killer cells by leukemia cells loaded with Toll-like receptor ligand: development of a new generation of leukemia vaccines. University of Antwerp

Zwi Berneman
Vaccine & Infectious Disease Institute (VAXINFECTIO)
In this project we will investigate the influence of acute myeloid leukemia cells loaded with Toll-like receptor (TLR) ligands on the activation of dendritic cells (DCs) and natural killer (NK) cells. The hypothesis is that leukemia cells loaded with TLR ligands are capable of activating the recently discovered helper function of NK cells, so these NK cells can effectuate the polarization of immature DCs to T helper type 1 (Th1)-polarised DCs ...

Effect of innate immune signals on leukemia cells for the stimulation of natural killer cells and T helper type 1-polarizing dendritic cells. University of Antwerp

Zwi Berneman
Vaccine & Infectious Disease Institute (VAXINFECTIO)
In this project, we will investigate the cellular and molecular determinants for optimal activation of human Th 1-polarized DC (DC 1 NK) in a AML tumor model. Our strategy will be to increase the immunogenicity of leukemia cells by loading them with TLR ligands whether or not in combination with transient transfection of immune-stimulating factors in order to trigger DC and NK activation for subsequent cross-priming of Thl/CTL cells.

Manipulation of dendritic cells and regulatory T cells for tolerance induction in autoimmune disease models. KU Leuven

Jan Ceuppens
Allergy and Clinical Immunology Research Group
Autoimmune diseases results from a harmful reaction of the immune system against certain cells or cell components of the patient. For example, in multiple sclerosis, misguided T lymphocytes recognize central nervous system myelin sheet antigens and mount a chronic inflammatory and destructive reaction against it. To initiate an immune reaction properly, T lymphocytes are dependent on specialized antigen-presenting cells: the dendritic cells, ...

Early events in the interaction of antigens/microorganisms with the intestinal epithelial cells and intestinal dendritic cells : development of new innovative oral delivery system. Ghent University

Eric Cox
Department of Medical and Forensic Pathology, Department of Pharmaceutics, Department of Translational Physiology, Infectiology and Public Health

Vaccination is regarded as the most efficient and cost-effective way to prevent infectious diseases.

Vaccine design nowadays focuses on the implementation of safer recombinant subunit vaccines. However, these recombinant subunit antigens are often poor immunogens and several strategies are currently under investigation to enhance their immunogenicity. The encapsulation of the antigens in biodegradable microparticulate delivery ...

Reinforcing the function of the main killer cells of the immune system in acute myeloid leukemia by interleukin-15-engineered dendritic cells. University of Antwerp

Evelien Smits
Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
Despite major medical advances, acute myeloid leukemia (AML) still has a poor prognosis with a 5-year survival rate of 26%. Therefore, there is a clear need for new effective therapies that can destroy remaining malignant cells, which are not killed after the standard treatment. At present, there is much interest in the use of dendritic cell (DC)-based vaccination, as this cell therapy is capable of mobilizing the patient's own immune system, ...

Recognition of alfaherpesvirus envelope glycoproteins by dendritic cells and natural killer cells Ghent University

Herman Favoreel
Department of Translational Physiology, Infectiology and Public Health

Dendritic cells and natural killer cells are crucial for an efficient immune response against alphaherpesviruses. These cells are able, via an unknown mechanism, to recognize alphaherpesvirus envelope glycoproteins. The aim of the project proposal is to unravel this mechanism, which will lead to new virological and immunological insights that may lead to new strategies to interfere with alphaherpesvirus infections.