Projects
Mechanisms of motor neuron degeneration in amyotrophic lateral sclerosis (ALS):Â cell death pathways and/or aberrant communication between cell body and neuromuscular junctions KU Leuven
Study the role of cell death in organ injury and/of degeneration. University of Antwerp
Enzymatic treatment for age-related macular degeneration and excessive burn scars Ghent University
Next to the cataract treatment, which is currently being validated in the IOF Advanced project F2017/IOF–dvanced /089, we identified two novel clinical applications with a high market potential for the enzymatic treatment. One application (also in opthalmology) is age-related macular degeneration (AMD), a common cause of irreversible loss of sight for which at the current time no treatment is available. The second clinical application is ...
The role of mechanical loading in cartilage homeostasis, degeneration and repair: a multi-scale approach. KU Leuven
DNA methylation study of the C9orf72 repeat expansion causing frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). University of Antwerp
Axonal determinants as modifiers of motor neuron degeneration - A translational approach. KU Leuven
Determining PGRN serum levels in Belgian frontotemporal lobar degeneration patients. University of Antwerp
Onset age variability in GRN-associated frontotemporal lobar degeneration: a high-throughput assay to identify functional onset age modifying variants. University of Antwerp
Harnessing adipocytes in regeneration Ghent University
Wound healing of the skin generally results in the formation of a scar that is characterized by excessive collagen deposition and absence of fat. The transfer of adipocytes, or fat cells, into wounded tissue can enhance regeneration in the context of chronic wounds and irradiated skin. However, the molecular mechanisms by which adipocytes accelerate tissue repair are largely unknown. We recently obtained a single-cell transcriptomics dataset ...