Projects
Mechanobiological optimization of regeneration in cell-enriched construct implants within degenerative Cartilages: a defect Repair method through restoring Energy AbsorpTION KU Leuven
Knee cartilage defects and consequent degeneration contribute to the development of osteoarthritis (OA). OA affects the mechanical integrity of the tissue, whose main function is to absorb shock and minimize peak loads in the underlying subchondral bone.
Tissue engineering methods propose solutions to OA by implanting chondrocyte cell-enriched hydrogel/scaffold constructs within degenerative cartilage defects. By applying mechanical ...
Frontotemporal lobar degeneration (FTLD), a young-onset dementia characterized by the progressive degeneration of the frontal and temporal lobes of the human brain. University of Antwerp
Arterial stiffening as a common pathophysiological mechanism in cardiac and kidney failure and brain degeneration. University of Antwerp
Bipotential progenitor cells to treat cardiac and skeletal muscle degeneration in a large animal model of Duchenne Muscular Dystrophy. KU Leuven
Duchenne Muscular Dystrophy (DMD) causes untreatable and progressive degeneration of cardiac and skeletal muscles. Cell therapies are emerging as curative approach to functionally regenerate damaged muscles, yet strategies to equally target both muscle types are still missing. Induced pluripotent stem cells (iPSCs) are raising new expectations in the field, given the unprecedented possibility of patient-matched cells virtually differentiating ...
Mining the extraordinary regeneration potential of Marchantia polymorpha to increase regeneration of crop species Ghent University
The plant lineage displays an unrivalled regeneration capacity that not only restores damaged tissue but can also give rise to whole plant bodies. Unfortunately, many economically and ecologically important species display a poor regeneration potential. E.g., many elite tree species are recalcitrant to routine propagation by stem cuttings. In agricultural species, the capacity to regenerate is even worse, as most cereals, including important ...
Can tissue regeneration be induced via redox manipulation? An indepth characterization of the redox signature during the initial steps of regeneration. Hasselt University
Exploiting exosomal-miRNA cargo effects on 2D and 3D cell systems and in vivo models of muscle degeneration KU Leuven
Muscular dystrophies are inherited neuromuscular disorders that primarily affect striated muscle, mainly characterized by progressive muscle wasting and weakness, leading to physical disability and a shortened life expectancy. In addition, muscle atrophy can be determined by chronic pathological conditions, including cachexia and sarcopenia. Novel therapeutic approaches aim at ameliorating the disease’s course, even if an etiologic cure has ...
Unraveling the contribution of local translation to NMJ degeneration in FUS-ALS. Flanders Institute for Biotechnology
Comparative Impact of Reconstruction Surgery versus Conservative Treatment on early Cartilage Degeneration Following Anterior Cruciate Ligament Injury: Profiling Knee Joint Loading and Biomarkers KU Leuven
Knee osteoarthritis (OA) leads to knee pain, mobility disability and socioeconomic cost worldwide 1) .Patients who had a previous knee injury (for example an ACL or meniscus injury) have a 10-fold increased risk to develop knee OA 3-10 years later. This means that these patients have knee OA at a very young age (on average 35-45 year old), resulting in knee pain and disability for a major part of their active life. Preventing (delay or halt) ...