Projects
Unraveling persister awakening mechanisms KU Leuven
Persister cells are temporarily antibiotic-tolerant cells that are present in every bacterial population. They can survive antibiotic treatment and once the antibiotic pressure in the environment drops below a critical value, they can exit the persister state and establish a new population. Although persisters were discovered in 1944, their clinical importance has only recently become apparent. Indeed, persister cells are associated with the ...
ADVANCED ORGANOID ASSAYS FOR MODELLING HUMAN DISEASE – OrganADVANCE KU Leuven
Translational research on chronic rejection after lung transplantation: towards better treatment in patients. KU Leuven
My BOF−ZAP project is part of the BREATHE research group and includes research into rejection after lung transplantation focusing on structural changes of the lung and the allo-immune response. This research ranges from basic experimental research in cell cultures and laboratory animals to translation to the human lung and the patient. The final objective remains to increase the quality and survival of the lung transplant patient. We aim to ...
The importance of IL-17 producing T lymphocytes in chronic rejection after lung transplantation. KU Leuven
Assessment and treatment of lung injury following brain death in a mouse model. KU Leuven
Rewriting drug-refractory CFTR mutations by prime editing KU Leuven
Specific objectives
1. To develop a prime editing (PE) strategy for the drug-refractory CFTR mutation N1303K
a. To identify the optimal PE system which balances efficiency, with safety and ease of delivery
b. To investigate cell-specific determinants of PE outcomes to establish the most translational model system to measure PE efficiency and outcome purity
2. To engineer Virus Like Particles (VLPs) for transient delivery ...
A MESO QuickPlex SQ system to measure single or multiple immunotargets in biofluids Ghent University
Multiplexed cytokine and chemokine analysis for the quantification of single or multiple immunotargets in biofluids is pivotal for the diagnosis and management of patients with systemic inflammatory disease. It allows early diagnosis of complex diseases, longitudinal monitoring and quantification of disease activation before and after targeted treatment, functional validation of novel disease-causing genes and finally the identification of ...
New machine-vision and automation methods for high throughput combinatorial drug screening KU Leuven
Combinatorial, High-throughput organoid screens for personalized medicine KU Leuven
Perspectives for patients with cystic fibrosis (CF) have dramatically changed over the last few years, with the advent of CFTR modulators, a new treatment class comprising several mutation-specific drugs. Recent drug development efforts are directed to the most frequent CFTR mutation (F508del) and a handful of less frequent mutations, excluding around 10% of patients with only rare mutations, who depend on academic research innovation and ...