Cystic fibrosis as a modulable model for mucosal and systemic immunity in airway disease. Ghent University
CFTR modulation equilibrates airway inflammation and systemic immune responses in CF patients. Blood and sputum samples are collected pre-/post-CFTR modulation into our prospective biobank. We will assess the role of CFTR in airway microenvironment and host immune response. CF patients will serve as the basis to study airway inflammation and host–microorganism interactions in the context of chronic microbial exposure.