Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative Vrije Universiteit Brussel
Up-regulation of carbonic anhydrase IX (CA IX) expression is an indicator of metastasis and associated with poor cancer patient prognosis. CA IX has emerged as a cancer drug target but development of isoform-specific inhibitors is challenging due to other highly conserved CA isoforms. In this study, a CA IX mimic construct was used (CA II with seven point ...