Publications
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Development of an Accurate and Efficient Method for Normal Mode Analysis in Extended Molecular Systems: the Mobile Block Hessian Method Ghent University
Vibrational spectroscopy is an important technique for the structural characterization of (bio)molecules and (nano)materials. For example, it is particularly suited for studying proteins in their natural environment (i.e., in aqueous solution), and can be used in many cases where other techniques such as Xray crystallography and nuclear magnetic resonance spectroscopy cannot be employed. In particular infrared (IR) and Raman spectroscopy have ...
The Discovery of Endoplasmic Reticulum Storage Disease. The Connection between an H&E Slide and the Brain KU Leuven
The revolutionary evolution in science and technology over the last few decades has made it possible to face more adequately three main challenges of modern medicine: changes in old diseases, the appearance of new diseases, and diseases that are unknown (mostly genetic), despite research efforts. In this paper we review the road travelled by pathologists in search of a method based upon the use of routine instruments and techniques which once ...
Detecting Molecular Rotational Dynamics Complementing the Low-Frequency Terahertz Vibrations in a Zirconium-Based Metal-Organic Framework KU Leuven
We show clear experimental evidence of cooperative terahertz (THz) dynamics observed below 3 THz (∼100 cm^{-1}), for a low-symmetry Zr-based metal-organic framework structure, termed MIL-140A [ZrO(O_{2}C-C_{6}H_{4}-CO_{2})]. Utilizing a combination of high-resolution inelastic neutron scattering and synchrotron radiation far-infrared spectroscopy, we measured low-energy vibrations originating from the hindered rotations of organic linkers, ...
An integrated electron microscopy study of prismatic and multiple sets of fine extinction bands in vein-quartz KU Leuven
Since the end of the nineteenth century fine extinction bands (FEBs) in quartz have been extensively studied by means of a polarized light microscope (PLM), universal-stage, and transmission electron microscopy (TEM). The last decade FEBs are additionally studied by electron backscatter diffraction orientation imaging (EBSD) on a scanning electron microscope (SEM) and cathodoluminescence (CL) spectroscopy on an electron probe micro-analyzer ...
Engineering the carbohydrate-binding site of Epa1p from Candida glabrata: generation of adhesin mutants with different carbohydrate specificity Vrije Universiteit Brussel Ghent University
The N-terminal domain of the Epa1p adhesin from Candida glabrata (N-Epa1p) is a calcium-dependent lectin, which confers the opportunistic yeast the ability to adhere to human epithelial cells. This lectin domain is able to interact with galactosides and, more precisely, with glycan molecules containing the Gal?-1,3-GalNAc disaccharide, also known as the T-antigen. Based on the crystallographic structure of the N-Epa1p domain and the role of the ...