NOVEL TOXIN FUSION PROTEINS Flanders Institute for Biotechnology
The present invention relates to the field of structural biology and drug discovery. More specifically, the present invention relates to novel fusion proteins, their uses and methods in three-dimensional structural analysis of macromolecules, such as X-ray crystallography and high-resolution Cryo-EM, and their use in structure-based drug design and screening, and as pharmacological tools. Even more specifically, the invention relates to a fusion of a venom toxin and a scaffold protein wherein the scaffold protein interrupts the topology of the toxin to form a rigid fusion protein that retains ...