Study of granuloma and giant cell formation in autoinflammatory diseases: focus on NOD2-associated Blau syndrome and Crohn's disease. KU Leuven
Granulomas are organized aggregates of predominantly macrophages which often fuse into multinucleated giant cells. In infectious diseases, granuloma formation is seen as a response of the immune system to segregate and remove persistent pathogens or large particles. Granulomas with multinucleated giant cells are also seen in chronic immune disorders without any bvious infectious trigger, including diverse autoimmune and autoinflammatory ...