Projects
AMPK: a master switch integrating metamoblism and immune effector functions in tumor-associated macrophages KU Leuven
Tumor-associated macrophages (TAMs) are the orchestrators of the inflammatory response in tumors. TAMs exist as a phenotypic spectrum ranging from tumoricidal M1-like macrophages (MOs) to pro-tumoral M2-like MOs. It is becoming clear that MOs alter their metabolism to meet the energetic requirements imposed by their functional polarization, but these processes are ill defined. MO heterogeneity reflects the plasticity and versatility of these ...
Clinical validation of a novel diagnostic medical device to assess gastric motility and sensitivity as key mediators in food tolerance KU Leuven
Critically ill patients are admitted to the intensive care unit for specialized and often life-saving therapy of an acute insult such as trauma, infection or surgery. International guidelines propose to initiate enteral nutrition as soon as possible at a low infusion speed when oral intake is insufficient. When tolerated, the speed can be gradually increased. However, gastrointestinal function is impaired in approximately one-third to half of ...
Importance of the subvalvular apparatus in functional mitral regurgitation: insights from in vitro and numerical modeling. Hasselt University
Study of the neuroimmune modulation within the gastrointestinal tract during sepsis: a translational approach. University of Antwerp
Importance of the subvalvular apparatus in functional mitral regurgitation: insights from in vitro and numerical modeling. Hasselt University
Structural biology of Interleukin-34, a novel cytokine ligand for colony stimulating factor 1 receptor (CSF-1R) Ghent University
We propose an interdisciplinary research project at the frontline of molecular structural biology to dissect the interaction of a novel cytokine, interleukin 34, with its hematopoietic RTKIII receptor, Colony Stimulating Factor1 Receptor. The proposed research project aims to elucidate the structural, kinetic and thermodynamic determinants that dictate this unusual cytokinereceptor specificity, using both experimental and computational ...