Fibrinolysis and proteolysis in bacterial spread and tissue destruction. KU Leuven
In this PhD project, we have studied the role of the host hemostatic system and its manipulation by S. aureus in the outcome of S. aureus infections.
It has long been known that most S. aureus strains produce staphylokinase. We have shown that staphylokinase-mediated fibrinolytic and proteolytic activity permit the local invasion of S. aureus in skin and soft tissue through degradation of fibrin and ...