Projects
Mucin isoform-microbiome crosstalk shaping the course of COVID-19: a help in patient stratification? University of Antwerp
Towards a more personalized approach of the ambulatory care for RA patients. KU Leuven
Background: Rheumatoid arthritis (RA) is a common, chronic inflammatory disease with a significant societal burden. The shift towards a 'treat to target' strategy has made ambulatory care for this condition more labor intensive and increased the importance of timely and personalized therapy adjustment. Patient-reported outcome measures (PROMs) carry the potential to improve understanding of disease remission and could be monitored via an ...
Gene therapy for HIV/AIDS based on the interaction of HIV-integrase with LEDGF/p75. KU Leuven
A study on how political debates shape citizens' trust judgement of politicians and the political system KU Leuven
While it is claimed repeatedly that political debates in the media have coarsened over time leading to detrimental effects on citizens’ political trust, little effort has been made to investigate this. The question how the media influence political trust is of paramount importance as political trust is a key resource for a democratic political system influencing citizens’ willingness to commit public resources to policy ends and accept ...
Behavioural change based on the self-categorisation theory: promotion of physical activity among sedentary older adults (intervention study among older adults on intrinsic and social determinants of physical activity and health-related behaviour). KU Leuven
Clinical and (patho)genetic study of bicuspid aortic valve and associated aortic aneurysm. University of Antwerp
Lung-on-a-chip as a dynamic tool to capture interplay between airway and vascular cells in their microenvironment: a focus on the course of chronic obstructive pulmonary disease KU Leuven
Chronic obstructive pulmonary disease (COPD), which is estimated to become the third leading cause of death worldwide by 2030, is actually the only major disease whose prevalence and mortality are increasing worldwide in all continents. Despite intensive research, there are still unmet medical needs for this disease. Abnormal responses of the airway epithelium to the environmental triggers are believed to contribute to the pathogenesis of ...
The regulation of photosynthesis by ethylene in tomato KU Leuven
Ethylene is a volatile plant hormone that plays a regulatory role in many aspects of vegetative plant growth and development, including the regulation of photosynthesis. It is also regarded as an 'aging' hormone, as it is required for processes such as climacteric fruit ripening, leaf and flower senescence, and abscission. In addition, ethylene is also involved in regulating plant responses to various biotic and abiotic stresses.
It ...
The time course of impaired glutamate transmission, neuroinflammation, glucose metabolism and structural changes in human Amyotrophic Lateral Sclerosis: an integrated multimodal PET/MR study KU Leuven
ALS is a neurodegenerative disease with progressive muscle loss and an average survival of 2 to 5 years after symptom onset. Until now, no curative treatment is available. The general aim of this PhD was to investigate a triad of interrelated in-vivo imaging biomarkers that may be used for diagnosis and prognosis and the study of their physiopathological significance in ALS: glucose metabolism, neuroinflammation and synaptic ...