Projects
Single-cell computation in auditory brainstem and its impact on cortical coding and behavior KU Leuven
The goal of the project is to learn how heterogenous sensory inputs are integrated by single brain cells to encode timing in sensory circuits. Towards this goal and to
meet requirements of the RFA, we need to observe how natural stimuli are processed by cells and circuits in real time in vivo.
Dr. Joris’ lab is the only one in the world performing in vivo physiology of octopus cells, building on years of experience studying ...
Visual processing of dynamic images of bodies in macaque cortical body patches. KU Leuven
The project aims to understand how the brain evolved special structures to process highly relevant social stimuli like bodies and to reveal how social vision sustains adaptive behaviour.
Offline learning during low-frequency rTMS intervention: effect on neuromodulation of cortical functions gauged with fMRI and EEG KU Leuven
Epicranial cortical stimulation: development and evaluation of a novel, minimally invasive, neuromodulation method KU Leuven
Invasive cortical stimulation (ICS) is an neuromodulation method in which electrodes are implanted on the cortex to deliver chronic stimulation. ICS has been used to treat neurological disorders such as neuropathic pain, movement disorders and tinnitus. A significant disadvantage of ICS is its highly invasive nature. Noninvasive neuromodulation methods such as transcranial magnetic stimulation and transcranial current stimulation show great ...
Transcriptional mechanisms of the neoteny of human cortical neurons KU Leuven
The human brain is characterized by its unique features, but the underlying developmental origins remain largely unknown. One important mechanism could be the unusually protracted rates of maturation of human cortical neurons, leading to neoteny of specific neuronal populations in the human cortex, compared with nonhuman primates (NHP). Very little is known about human neuronal neoteny, but interestingly it is also observed in human cortical ...
Transcriptional mechanisms of the temporal control of human cortical neuron differentiation. KU Leuven
The human brain is characterized by unique cognitive features, but the underlying developmental origins remain largely unknown. One important mechanism could be the unusually slow rates of maturation of human cortical neurons, leading to a so-called neoteny of specific neuronal populations in the human cortex, compared with non-human primates. Very little is known about the mechanisms underlying the speed of maturation of neurons, but it is ...
Effect of hearing loss and vestibular decline on cognitive function in older subjects: correlation with cortical auditory evoked potentials and mri brain volume changes. University of Antwerp
From pluripotent stem cells to cortical circuits KU Leuven
Understanding the mechanisms of human brain development constitutes a fascinating and crucial challenge in biology and medicine, for which novel tools and approaches need to be developped, in order to tackle its complexity in health and disease. The advent of pluripotent stem cell (PSC)-based reductionist models provides novel opportunities to model brain diseases and in a longer prospect for brain repair therapies. Taking advantage of our ...