Projects
De rol van de prefrontale cortex, hippocampus en visuele cortex in categorie leren bij de rat. KU Leuven
In the PFC, we will apply electrolytic lesions based on the ISH results to further demonstrate the importance of the PFC in a causal way. To investigate the expression of membrane proteins in the PFC in function of the task, we will use a gel-free differential proteomics strategy and mass spectrometry. Collaboration In this project, cooperation with Prof. Dr. Dr. Rudi D'Hooge and met Prof. Dr. Balshun for complementary electrophysiological ...
Structure and function of the cerebral cortex in human and nonhuman patients: from single cells to deficits in patients (Leuven Cerebral Cortex Center). KU Leuven
Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex combined with neurofeedback of the subgenual anterior cingulate cortex as a patient-specific intervention with lasting effects Ghent University
Repetitive Transcranial Magnetic Stimulation over the dorsolateral prefrontal cortex combined with tomographic neurofeedback of the subgenual anterior cingulate cortex as a tailored antidepressant intervention with enduring effects. Ghent University
I aim to develop an antidepressant intervention based on the modulation of the prefrontal/limbic network via two angles:
(1) a cortical entry point (via neuro-cardiac guided neurostimulation)
(2) a subcortical entry point (via neurofeedback).
I hypothesize that the combined treatment will translate in synergistic effects on clinical outcome with enduring effects.
Characterization of the distinct impact of one-eyed vision on monocular cortex: a molecular, cellular and systems level analysis of cross-modal brain plasticity in the adult mouse KU Leuven
One of the best-studied examples of experience- and age-dependent modifications of neuronal circuits in the brain is ocular dominance plasticity. Although it is involved in the reactivation of the binocular visual cortex after the loss of one eye, it does not explain the recovery of the simultaneously deprived monocular zone. This suggests brain region-specific modifications of the circuitry and/or molecular pathways to cope with the sensory ...
Characterization of the distinct impact of one-eyed vision on monocular cortex: a molecular, cellular and systems level analysis of cross-modal brain plasticity in the adult mouse. University of Antwerp
Neural mechanisms of adaptation in inferior temporal cortex: an optogenetic and pharmacological analysis. KU Leuven
Neurons in sensory brain areas change their responses to a stimulus after being exposed recently to that stimulus. This “adaptation” is a kind of short-term plasticity of the brain. Adaptation effects vary amongst brain regions and range from a suppression of the response to a repeated stimulus (“repetition suppression”) to an enhancement of the response to repeated stimuli. Repetition suppression is prominent in the inferior temporal (IT) ...