Projects
TOWARDS UNDERSTANDING THE FUNDAMENTAL ASPECTS OF SECRETION MECHANISMS IN E. COLI (Cytoplasmome/secretome divide in E. coli and in vitro reconstitution of the Type 3 Secretion in EPEC) KU Leuven
To function properly, proteins need to reach their final sub-cellular destinations and acquire their final folded state. Therefore, protein targeting and transport are essential cellular processes in all kingdoms of life. Understanding how proteins become transported and folded into a functional state reveals the fundamental aspects of cellular protein biology, like cell wall biogenesis, cell division, molecule-export/uptake/degradation ...
EU PAL COPD : Evaluation of the ICLEAR-EU intervention to integrate palliative care in the treatment of people with advanced COPD and their family caregivers: An international stepped wedge cluster RCT in six European countries. Vrije Universiteit Brussel
Worldwide, COPD is the third leading cause of death. The symptom burden of people with COPD is as severe and burdensome as
the symptom burden of people with lung COPD. While palliative care in many countries is available for people with lung COPD,
palliative care and good end-of-life care for ...
Receptor-based anti-adhesive molecules as prophylactic treatment of F4+ E. coli and F18+ E. coli infections in young piglets. Ghent University
In this project, we will firstly develop a screening system for inhibitors of F4+ and F18+ E. coli adhesion to intestinal receptors. Secondly, we aim to develop a prophylactic treatment against F4+ and F18+ E. coli infections in pigs. Hereto, we will use our fundamental knowledge of the F4- and F18 receptors involved in adherence.
Identification and optimization of ethanol tolerance mechanisms in Escherichia coli by means of experimental evolution. KU Leuven
Fossil fuel reserves are declining while energy demands continue to increase. Therefore, solving the energy issue poses one of the greatest challenges of the 21st century. Over the past decades, multiple efforts have been undertaken to facilitate the switch from fossil fuels to renewable biofuels. Especially bioethanol has gained much attention. It is one of the biofuels that is already widely integrated in our society. Ethanol is produced in ...
Development of Computational Methods to Detect Copy Number Alterations in Human Genomes KU Leuven
Copying the master or mastering the copy? Creative copying as a mediator between artistic practice and emerging art theory in the early 16th-century Low Countries. Ghent University
We investigate creative copying as a catalyst for art theory in the early 16th-century Low Countries. We define the status and function of creative copying in the altering art practice and theory by unraveling underlying visual strategies. We thus elucidate how creative copying generated opportunities to enrich art with theories of imitation and enforce pictorial innovations in the Northern decorum.
Mapping the functional role of the low copy repeats in the phenotypic variability of the 22q11.2 Deletion Syndrome KU Leuven
The 22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal microdeletion disorder in humans with an estimated incidence of 1 in 3000 live births. The patient’s phenotype is highly heterogeneous and includes congenital heart defects, palatal anomalies and neuropsychological disorders such as schizophrenia which affects 30% of the carriers. These features however are never fully penetrant and the reason for their variability ...
Mapping the role of the low copy repeats in the phenotypic variability of the 22q11 Deletion Syndrome KU Leuven
The 22q11 deletion syndrome (22q11DS) is the most common
genomic disorder, with a prevalence of 1 in 3000 births. The reason
for this high incidence remains an enigma. The presence and
degrees of severity of most phenotypic features are highly variable
across patients and it remains unknown why some patients acquire
neuropsychiatric features and others do not. The deletion is caused
by non-allelic homologous ...