Clinical pharmacology of exogenously administered alkaline phosphatase University of Antwerp
Purpose To evaluate the clinical pharmacology of exogenous alkaline phosphatase (AP). Methods Randomized, double-blind, placebo-controlled sequential protocols of (1) ascending doses and infusion duration (volunteers) and (2) fixed dose and duration (patients) were conducted at clinical pharmacology and intensive care units. A total of 103 subjects (67 male volunteers and 36 patients with severe sepsis) were administered exogenous, 10-min IV ...