Closing the neural tube: gene-gene interactions of TET1 and the interplay with nutrient metabolism KU Leuven
The etiology of congenital malformations, particularly neural tube defects (NTDs), is complex, and involves a combination of genetic and environmental factors affecting each other. Understanding the relationship between intrinsic genetic factors and extrinsic environmental factors has been challenging. Here in this thesis, I describe my efforts to improve our understanding of the epigenome-gene-environment interaction model. Of particular ...