Development of decision support systems to manage QT-prolongation in clinical practice. KU Leuven
The risk of QTc-prolongation has become an important issue in drug safety. In rare cases it can lead to serious adverse events like Torsade de Pointes and sudden cardiac death. In the last decades, several drugs have been removed from the market (e.g. cisapride) or restricted in use (e.g. domperidone, (es)citalopram) because of this risk. At the moment, more than 170 drugs are linked with this risk of QTc-prolongation, as defined in the ...