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Palliative Care in Early Dementia Vrije Universiteit Brussel Ghent University

Karen de Sola-Smith, Joni Gilissen, Jenny T. van der Steen, Inbal Mayan, Lieve Van den Block, Christine S Ritchie, Lauren J Hunt

BACKGROUND: Palliative care is recommended for all people with dementia from diagnosis through end-of-life. However, palliative care needs and effective elements of palliative care are not well-defined for the earlier stages of dementia.

OBJECTIVE: To systematically map current research on palliative care early in the disease trajectory of dementia.

DESIGN: Scoping review of scientific literature.

DATA SOURCES: PubMed, ...

Screening and management of hypertensive patients with chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. A pilot survey based on questionnaire Vrije Universiteit Brussel

Jean-Michel Halimi, Pantelis Sarafidis, Michel Azizi, Grzegorz Bilo, Thilo Burkard, michael bursztyn, Miguel Camafort, Neil Chapman, Santina Cottone, Tine De Backer, et al.

OBJECTIVE: Real-life management of hypertensive patients with chronic kidney disease (CKD) is unclear.

METHODS: A survey was conducted in 2023 by the European Society of Hypertension (ESH) to assess management of CKD patients referred to ESH-Hypertension Excellence Centres (ESH-ECs) at first referral visit. The questionnaire contained 64 questions with which ESH-ECs representatives were asked to estimate preexisting CKD management ...

Cognitive Behavioral Therapy for Insomnia in Pain Management for Nonspecific Chronic Spinal Pain Vrije Universiteit Brussel

Anneleen Malfliet, Liesbet De Baets, Thomas Bilterys, Eveline Van Looveren, Olivier Mairesse, Barbara Cagnie, Mira Meeus, Maarten Moens, Dorien Goubert, Wouter Munneke, et al.

IMPORTANCE Insomnia is highly prevalent in patients with nonspecific chronic spinal pain (nCSP). Given the close interaction between insomnia and pain, targeting sleep problems during therapy could improve treatment outcomes. OBJECTIVE To evaluate the effectiveness of cognitive behavioral therapy for insomnia (CBTi) integrated in best-evidence pain management (BEPM) vs BEPM only in patients with nCSP and insomnia. DESIGN, SETTING, AND ...

Incidence of contralateral metachronous inguinal hernia on long term follow-up after unilateral inguinal hernia repair: a systematic review and meta-analysis KU Leuven

Nele Van de Winkel, Marc Miserez
BACKGROUND: The repair of inguinal hernias is a common surgical procedure. Some patients will need a second operation after developing a metachronous contralateral inguinal hernia (MCIH). The suggestion has been made to strengthen the contralateral side at the same time as primary unilateral surgery. In this systematic review we aim to determine how many adult patients with a unilateral inguinal hernia will develop a MCIH. METHODS: This review ...

Relatives' needs in terms of bereavement care throughout euthanasia processes Vrije Universiteit Brussel

Charlotte Boven, Let Dillen, Liesbeth Van Humbeeck, Lieve Van den Block, Ruth D Piers, Nele Van Den Noortgate

AIM: To explore relatives' needs in terms of bereavement care during euthanasia processes, how healthcare providers respond to these needs, and the degree of commonality between relatives' and healthcare providers' reports.

DESIGN: A phenomenological design was employed, utilising reflexive thematic analysis to examine interviews conducted with relatives (N = 19) and healthcare providers (N = 47).

RESULTS: Relatives' needs ...

Epigenetic Landscapes of Pain: DNA Methylation Dynamics in Chronic Pain KU Leuven Vrije Universiteit Brussel

Jolien Hendrix, Lode Godderis, Andrea Polli
Chronic pain is a prevalent condition with a multifaceted pathogenesis, where epigenetic modifications, particularly DNA methylation, might play an important role. This review delves into the intricate mechanisms by which DNA methylation and demethylation regulate genes associated with nociception and pain perception in nociceptive pathways. We explore the dynamic nature of these epigenetic processes, mediated by DNA methyltransferases (DNMTs) ...

Recombinant human placental growth factor-2 in post-infarction left ventricular dysfunction: a randomized, placebo-controlled, preclinical study KU Leuven

Peter Pokreisz, Piet Claus
Placental growth factor (PlGF)-2 induces angio- and arteriogenesis in rodents but its therapeutic potential in a clinically representative post-infarction left ventricular (LV) dysfunction model remains unclear. We, therefore, investigated the safety and efficacy of recombinant human (rh)PlGF-2 in the infarcted porcine heart in a randomized, placebo-controlled blinded study. We induced myocardial infarction (MI) in pigs using 75 min mid-LAD ...

Challenges in posttransplantation care for kidney transplant recipients: A qualitative study highlighting gaps in psychological, social and exercise support KU Leuven

Marie Renier, Stefan De Smet
BACKGROUND: Kidney transplantation offers meaningful health improvements compared to dialysis, yet the quality of life and life expectancy of kidney transplant recipients still lag behind those of their healthy peers. Physical inactivity and poor physical fitness are prevalent among kidney transplant recipients, affecting overall life participation. OBJECTIVES: To explore challenges hindering life participation for kidney transplant recipients ...

A prospective, randomized, controlled, double-blind, multi-center study to evaluate the efficacy and safety of a blue light device for the treatment of chronic back pain KU Leuven

Bart Morlion
INTRODUCTION: Chronic back pain is one of the most prevalent conditions and has a large socio-economic impact. The lack of routine use of non-pharmacological options and issues associated with pharmacological treatments underscore high unmet needs in the treatment of back pain. Although blue light phototherapy has proven efficacy in dermatology, limited information is available about its use in back pain. METHODS: In this proof-of-concept, ...

Irritable bowel syndrome: When food is a pain in the gut KU Leuven

Hind Hussein, Guy Boeckxstaens
Irritable bowel syndrome (IBS) is a chronic gastrointestinal condition associated with altered bowel habits and recurrent abdominal pain, often triggered by food intake. Current treatments focus on improving stool pattern, but effective treatments for pain in IBS are still lacking due to our limited understanding of pathophysiological mechanisms. Visceral hypersensitivity (VHS), or abnormal visceral pain perception, underlies abdominal pain ...