Characterization of CXCR3 ligand proteoforms in inflammatory lung and joint diseases for identification of therapeutic targets KU Leuven
The chemokines CXCL9, CXCL10 and CXCL11 orchestrate directional trafficking of activated T cells and NK cells through interaction with the G protein-coupled CXC chemokine receptor 3 (CXCR3) and glycosaminoglycans (GAGs). The mRNA for CXCR3 ligands and high protein levels have been reported in cancer, acute and chronic inflammation. Moreover, for all three CXCR3 protein ligands posttranslational modification (PTM) has been reported and some ...