Projects
Chromatin signaling by protein phosphatase PP1/Repo-Man. KU Leuven
Molecular mode of action of 1,25-dihydroxyvitamin D3: from chromatin to protein. KU Leuven
Optimizing an experimental approach to silence disease-related genes by interfering with their chromatin structure. Epigenetic silencing of the human androgen receptor. KU Leuven
Integration of cellular signaling pathways in health and disease. KU Leuven
The oncogenic JAK-STAT signaling network in T-cell acute lymphoblastic leukemia and its link with epigenetic changes and RNA metabolism KU Leuven
T-cell acute lymphoblastic leukemia is an aggressive hematological malignancy, characterized by the uncontrolled proliferation of immature lymphocytes in the bone marrow. Though treatment has become highly effective in children, there is still an unmet medical need. In the relapse/refractory setting or for adult patients, treatment outcome and 5-year survival remain poor. Treatment consists of complex and intensive chemotherapy regimens, with ...
Disentangling the complexity and diversity of glucocorticoid receptor signaling Ghent University
Synthetic glucocorticoids (GCs) are frequently used to treat various inflammatory and immune disorders. Unfortunately, long-term GC treatment is associated with many side effects. GCs bind to the glucocorticoid receptor (GR), an intracellular steroid receptor. Identifying improved GR ligands depends has been met with little success so far. Commonly used bio-assays do not fully capture the complex biology of how different GC ligands transmit ...
Sex hormone signaling in hepatic metabolic memory Ghent University
Sex hormones are considered as the main drivers for hepatic sexual dimorphism, with male and female livers displaying important differences in physiological and pathological processes. This is exemplified by the higher prevalence of nonalcoholic steatohepatitis (NASH) in men. While being a core element of disease management, weight loss and the associated benefits on hepatic inflammation and fibrosis are difficult to sustain on the long run, ...