Projects
Optimizing an experimental approach to silence disease-related genes by interfering with their chromatin structure. Epigenetic silencing of the human androgen receptor. KU Leuven
Sex hormone signaling in hepatic metabolic memory Ghent University
Sex hormones are considered as the main drivers for hepatic sexual dimorphism, with male and female livers displaying important differences in physiological and pathological processes. This is exemplified by the higher prevalence of nonalcoholic steatohepatitis (NASH) in men. While being a core element of disease management, weight loss and the associated benefits on hepatic inflammation and fibrosis are difficult to sustain on the long run, ...
Mapping (+)-jq1-chromatin interactions to characterize its ferroptosis-sensitizing effect. University of Antwerp
Study of crosstalk between GPCR-mediated signals and the NF-kappaB signal transduction cascade. Ghent University
Nuclear Factor κB (NF-κB) is a ubiquitously expressed transcription factor for genes involved in inflammation. The transcription of NF-κB-dependent genes can be altered by crosstalk with other signaling pathways. Recently, it has become evident that G-protein-coupled receptors (GPCRs) are implicated in immunity and that there is connectivity with NF-κB signaling. One of the GPCRs, that has received a lot of attention in the field of ...
Early detection of Alzheimer's disease with causal generative AI University of Antwerp
Regulation of Self−Renewal, differentiation and Reprogramming through Wnt/B-catenin and the Tcf/Lef factors. KU Leuven
Activation of Wnt signaling can drive embryonic stem cells into opposite directions: self−renewal or ESCs differentiation. Futhermore we have demonstrated that a tuned regulation of the pathway also increase somatic cell reprogramming. How activation of the same Wnt/β−catenin signal yields disparate effects in different cell types, remains poorly understood. I hypothesize that the difference lies in the downstream effectors of the ...