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Chikungunya virus infection in Aruba Institute of Tropical Medicine KU Leuven University of Antwerp
BACKGROUND: Chikungunya virus (CHIKV) emerged in Aruba for the first time in 2014. We studied the clinical presentation of acute CHIKV infection and the contribution of serologic and molecular assays to its diagnosis. In a cohort of confirmed CHIKV cases, we analysed the frequency, duration and predictors of post-chikungunya chronic polyarthralgia (pCHIK-CPA), defined as joint pains lasting longer than 6 weeks or longer than 1 year.
...Dengue and chikungunya among outpatients with acute undifferentiated fever in Kinshasa, Democratic Republic of Congo: a cross-sectional study Institute of Tropical Medicine University of Antwerp
Background: Pathogens causing acute fever, with the exception of malaria, remain largely unidentified in sub-Saharan Africa, given the local unavailability of diagnostic tests and the broad differential diagnosis.
Methodology: We conducted a cross-sectional study including outpatient acute undifferentiated fever in both children and adults, between November 2015 and June 2016 in Kinshasa, Democratic Republic of Congo. Serological and ...
Challenges in diagnosis and management of chikungunya and Zika virus infections Institute of Tropical Medicine
Chikungunya virus (CHIKV) and Zika virus (ZIKV) have emerged as pathogens of global importance. They belong to different virus families (Togaviridae and Flaviviridae, respectively), but both arboviruses are primarily transmitted by widely distributed Aedes species mosquitoes. The studies in this doctoral thesis aim to advance our understanding of the risk factors, clinical presentation and diagnosis of CHIKV and ZIKV infections.
The ...
The ...
Challenges in diagnosis and management of chikungunya and Zika virus infections KU Leuven
Arthropod-borne viruses (arboviruses) are viruses that can be transmitted between animal or human hosts by arthropod vectors, such as mosquitoes, ticks and sandflies. Transmission of virus occurs when the arthropod bites the host to feed on his blood. An infectious bite may then lead to a wide range of symptoms, from inapparent (asymptomatic) to severe disease and death. Approximately 150 virus species are known to cause human disease, and some ...
Clinical evaluation of BioFire® multiplex-PCR panel for acute undifferentiated febrile illnesses in travellers: a prospective multicenter study Institute of Tropical Medicine
BACKGROUND: Identifying the causes of Acute Undifferentiated Febrile Illness (AUFI) is key to improve the management of returning travellers with fever. We evaluated a BioFire®FilmArray® prototype panel of multiplex nucleic acid amplification tests (NAAT) targeting different relevant pathogens in travellers returning with fever.
METHODS: Prospective, multicentre study to evaluate a prototype panel in whole blood samples of adult ...
A comparison of indirect immunofluorescence and electron microscopy for the diagnosis of some haemorrhagic viruses in cell cultures Institute of Tropical Medicine
Koorts Institute of Tropical Medicine
Emerging souvenirs-clinical presentation of the returning traveller with imported arbovirus infections in Europe University of Antwerp
Background: Arboviruses are an emerging group of viruses that are causing increasing health concerns globally, including in Europe. Clinical presentation usually consists of a nonspecific febrile illness that may be accompanied by rash, arthralgia and arthritis, with or without neurological or haemorrhagic syndromes. The range of differential diagnoses of other infectious and noninfectious aetiologies is broad, presenting a challenge for ...
Causes of fever in returning travelers: a European multicenter prospective cohort study Institute of Tropical Medicine
BACKGROUND: Etiological diagnosis of febrile illnesses in returning travelers is a great challenge, particularly when presenting with no focal symptoms (acute undifferentiated febrile illnesses (AUFI)), but is crucial to guide clinical decisions and public health policies. In this study, we describe the frequencies and predictors of the main causes of fever in travelers.
METHODS: Prospective European multicenter cohort study of ...