Development Of Immobilized Microenzyme Reactors (IMERs) Of Flavin Monooxygenase And Sulfotransferases Using Magnetic Nano/Microparticles And In-Line Capillary Electrophoresis. KU Leuven
The investigation of the metabolism of new chemical entities is an important step in the drug development process. It preferably takes place at an early stage of this process, and requires quick, affordable and efficient test systems. In this project, we aim to immobilize various metabolizing enzymes like the FMO (Flavin monoxygenase), SULT (sulfotransferase) on magnetic nanoparticles (MNs) accommodated with different functional groups on ...