Publications
Impact of physiologically inspired boundary conditions on fluid pressure and flow in a computational fluid dynamics model of the cerebrospinal fluid Ghent University
Computational fluid dynamics study to investigate the impact of sudden physiological actions on cerebrospinal fluid pressure and flow Ghent University
Implementing physiological processes in computational fluid dynamics models of the cerebrospinal fluid Ghent University
Neuronal and glia-related biomarkers in cerebrospinal fluid of patients with acute ischemic stroke Vrije Universiteit Brussel University of Antwerp
BACKGROUND: Cerebral ischemia promotes morphological reactions of the neurons, astrocytes, oligodendrocytes, and microglia in experimental studies. Our aim was to examine the profile of CSF (cerebrospinal fluid) biomarkers and their relation to stroke severity and degree of white matter lesions (WML).
METHODS: A total of 20 patients (mean age 76 years) were included within 5-10 days after acute ischemic stroke (AIS) onset. Stroke ...
Genes involved in cerebrospinal fluid production as candidate genes for late onset Alzheimer's disease: a hypothesis Ghent University University of Antwerp
sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers Vrije Universiteit Brussel University of Antwerp
TREM2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of TREM2 are associated with increased risk of Alzheimer's disease (AD). TREM2 is a type-1 protein with an ectodomain that is proteolytically cleaved and released into the extracellular space as a soluble variant (sTREM2), which can be measured in the cerebrospinal fluid (CSF). In this cross-sectional multicenter study, we investigated whether ...
Procarboxypeptidase U (proCPU, TAFI, proCPB2) in cerebrospinal fluid during ischemic stroke is associated with stroke progression, outcome and blood-brain barrier dysfunction Vrije Universiteit Brussel University of Antwerp
Essentials Little is known of procarboxypeptidase U (proCPU) in cerebrospinal fluid (CSF) of stroke patients. ProCPU levels were studied in CSF of controls and non-thrombolyzed acute ischemic stroke patients. ProCPU is elevated in CSF of stroke patients compared with controls. ProCPU in CSF correlates with stroke progression, outcome, and blood-brain barrier dysfunction. Summary: Background Procarboxypeptidase U (proCPU, TAFI, proCPB2), the ...
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias Vrije Universiteit Brussel University of Antwerp
In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. New concepts of Alzheimer's disease (AD) and the conceptual interactions between AD and dementia due to AD were developed, resulting in two sets for diagnostic/research criteria. ...