Projects
A novel bacterial cell death pathway targeted by a poisoned a corrupt cell cycle control. KU Leuven
A dynamical analysis of the regulation of the cell cycle in space and time KU Leuven
The cell division cycle is a crucial biological process, essential for development and survival of all organisms. In eukaryotes, the cell cycle is regulated by an intricate network of genes and proteins that controls the progress of the cycle. All of these interactions give rise to dynamical features such as bistability and time delay which aid in the coordination of cell cycle events. Understanding this complex interplay has been helped by ...
The role of self-organizing patterns in the coordination of the cell cycle KU Leuven
A high-throughput quantitative study of the early embryonic cell cycle KU Leuven
Functional analysis of transcription factors involved in cell cycle regulation of plants, by a new generic tool based on tandem affinity purification and deep sequencing. Ghent University
An efficient method to determine the target genes of transcription factors is lacking in plant molecular research. It is nevertheless important to gain insight into the function of transcription factors, since they are important regulators of biological functions. In this project, a new generic method will be developed to identify target genes of transcription factors in plant cells, based on tandem affinity purification and deep sequencing. ...
Overcoming cell cycle arrest in injured kidneys: key to efficient renal regeneration. University of Antwerp
Influence of Temperature on Cell Cycle Progression KU Leuven
Cold-blooded animals, such as Reptilia, and warm-blooded as Mammalia, adapt to environmental temperature changes in a very different way. While the latter has evolved to maintain a high and constant body temperature by metabolic means, cold-blooded animals largely adopt their ambient temperature. In this project, I aim to answer to a deceivingly simple, yet fundamental, question of how each cell responds to changes in temperature. I will ...
Mathematical modeling of nuclei as pacemakers of cell cycle oscillations KU Leuven
In this project the student will theoretically analyze how cell division is spatially and temporally coordinated. Using computational modeling, the student will first uncover how multiple functional motifs (such as bistable switches) can optimally work together to create different desired cell responses in time. Second, the student will develop models to show how the cell cycle is dynamically coordinated in space. Special attention will be ...
Regulation of the protein phosphatase scaffold RepoMan during the cell cycle KU Leuven
Protein kinases and phosphatases are antagonistically acting enzymes that cooperate to control the speed, amplitude and specificity of phosphorylation signals in numerous cellular processes, including mitosis. Early mitotic events are characterized by bulk phosphorylation of specific proteins by kinases such as CDK1/Cyclin B and Aurora B. The mitotic exit depends on protein phosphatases, mainly PP1 and PP2A, which remove phosphate groups from ...