Projects
Process monitoring and controlled biomanufacturing of human periosteum derived progenitor cells for cell therapy applications KU Leuven
Cell-based products are an important innovation on the pharmaceutical market. These advanced therapy medicinal products are able to regenerate defects or treat diseases, where other pharmaceuticals fail or only treat the symptoms instead of the disease. The applications of such cell-based therapies vary between treating cancer with chimeric antigen receptor T-cell therapy and regenerating cartilage or bone defects with a cell-based tissue ...
SRP-Onderzoekszwaartepunt: PACT: multi-omics Profiling of T cells to improve Adoptive Cell Therapy Vrije Universiteit Brussel
Dental stem cells as effective vehicles in a new therapy for oral squamous cell carcinoma. Hasselt University
Kidney stem/progenitor cells as a potent source for kidney-targeted cell therapy KU Leuven
Kidney stem/progenitor cells as a potent source for kidney-targeted cell therapy. KU Leuven
Chronic kidney disease affects 1 in 10 people worldwide with a significant proportion of patients progressing towards kidney failure. For these patients, kidney transplantation represents the treatment of choice. However, the success of this treatment depends on the availability of kidney grafts, which currently points out to a shortage of organs. At the same time, a considerable amount of donated kidneys are declined for transplantation due ...
Kidney stem/progenitor cells as a potent source for kidney-targeted cell therapy KU Leuven
End stage kidney disease (ESKD) is the result of a permanent failure of the kidneys. Kidney failure is caused by the irreversible loss of nephrons, the structural and functional units of the kidney. Although the final patterned and segmented nephrons contain numerous functionally distinct cell types, lineage tracing showed that all these cell types are derived from a SIX2+ progenitor’s population at the kidney cap mesenchyme (CM). The ...
Mechanisms affecting the homing, engraftment and functioning of hematopoietic stem cells in a compromised bone marrow environment: relevance to treatment of the elderly cancer patient by stem cell therapy KU Leuven
Most people diagnosed with cancer, including a variety of life-threatening hematologic malignancies, are over 65 years old. The options and outcomes of treating the elderly cancer patient with hematopoietic stem cell (HSC) therapy are limited. Achieving better long-term engraftment following transplantation in this growing target group will rely on profound knowledge of the interactions between HSCs and the bone marrow (BM) environment, ...
The Neurogenin 3 cell as a guide for cell therapy in diabetes. Vrije Universiteit Brussel
The generation of bona fide T cell precursors for cell therapy Ghent University
T cells are white blood cells that play an essential role in the immune system to clear infections and kill tumor cells. As a result, promoting the recovery of T cell immunity is an important therapeutic strategy in numerous clinical settings, such as following stem cell transplantation. In addition, T cells are increasingly exploited in the battle against cancer. In this setting, T cells from the patient are isolated, subsequently ...