Projects
Innovative polymer scaffold for artificial meniscus replacement: from ‘zero-design’ to premium functional implantable device. Ghent University
This project is the second stage of a large research project aiming at the development of a 3D printed, personalized tissue engineered meniscal replacement that would provide a natural and durable solution to meniscal injury whilst preserving articular cartilage. In this StarTT proposal, we would like to investigate the biomechanical and tribological characteristics of a proprietary polymer scaffold developed at PBM UGent, its suturability ...
Development of a cutting-edge service platform for in vivo preclinical testing of drug candidates able to treat chronic kidney disease and its associated co-morbidities. University of Antwerp
GENOmics in MEDicine: From whole genome sequencing towards personalized medicine (GENOMED). University of Antwerp
Role and regulation of osteogenic cell adhesion and cytoskeletal dynamics during bone homeostasis and repair KU Leuven
Screening and Development of Contrast-Enhancing Staining Agents for CECT Imaging KU Leuven
The visualization of the composition and the spatial organization of tissues is of paramount importance to better understand their functioning and the impact of a disease. Microfocus X‐ray computed tomography (microCT) is a valuable tool for 3D imaging to complement classical 2D histological imaging techniques. In the last two decades, the incorporation of contrast‐enhancing staining agents (CESAs) has augmented the applicability of microCT ...
Plasma-assisted deposition of anisotropic multifunctional coatings on 3D porous scaffolds Ghent University
This project has the challenging goal to investigate the deposition of gradient multifunctional coatings throughout the interior of 3D scaffolds for interface tissue engineering applications such as the regeneration of damages at the bone-cartilage interface. Gradient coatings have been developed in the past via wet chemical approaches, but often suffer from severe stability issues.
To tackle this fundamental problem, an alternative ...
In-vitro Paraxial Mesoderm Morphogenesis in 3D Artificial Extracellular Micro Environments KU Leuven
Paraxial mesoderm plays a significant role in somitogenesis, which further gives rise to skeletal muscle, tendon, cartilage and skin. In vitro studies have been mainly performed in 2D culture; however, this system can be overly reductionistic and disregards the complexity of the physiological structures, including multicellular interaction and the interaction between cells and extracellular matrices (ECM) . By utilizing 3D organoid culture ...
Biomechanische determinanten en patronen geassocieerd aan de pathophysiologische enkelarthropathie cascade van kinderen met haemophilie. KU Leuven
Haemophilia is a X chromosome-linked coagulation disorder resulting from a congenital deficiency or absence of circulating factor VIII or factor IX. Patients with haemophilia are unable to generate adequate thrombin resulting in abnormal bleeding. Approximately 80-90% of bleeding episodes occur in the musculoskeletal system, especially in the large synovial joints and muscles. Repeated haemarthrosis induces joint cartilage damage and ...
Mucosal wound healing and regeneration in chronic upper airway diseases. Ghent University
Wound healing and scar formation is a frequent problem encountered after functional endoscopic sinus surgery for chronic rhinosinusitis and nasal polyps. In this project we will identify negative factors influence epithelial regeneration and based on this findings develop therapeutic strategies, using an in vitro model tissue engineering of epithelium and cartilage and a pharmacologic trial.