Projects
Probing local ROS distributions in Calcium signaling microdomains after myocardial infarction KU Leuven
An increasing number of people suffer cardiovascular diseases and experience myocardial infarction (MI). The subsequent heart remodeling is characterized by weaker contractility, hypertrophy and lethal arrhythmias. The poorly-understood underlying mechanism is related to calcium (Ca2+) mishandling in cardiomyocytes and oxidative stress. To date, most of the studies described global cellular processes and were unable to propose efficient ...
Carbohydrates: friend or foe of obesity and its complications? KU Leuven
With more than 650 million patients worldwide and a prevalence that will only increase further, obesity has become one of the biggest health-threats of the 21st century. Obesity is such a big problem because it induces a systemic inflammation that causes a lot of co-morbidities including cardiovascular disease and cancer. The biggest risk factor for obesity and obesity-associated inflammation is a western diet, high in fat and carbohydrates. ...
Trans Tech Diagnostics Hasselt University
Targeting arterial stiffening to prevent incident hypertension and associated organ damage. University of Antwerp
Therapeutic potential of high-density lipoproteins in heart failure with reduced ejection fraction KU Leuven
Plasma high-density lipoprotein (HDL) cholesterol levels and plasma levels of its major apolipoprotein (apo), apo A-I, are inversely correlated with the incidence of coronary heart disease. The potential protection conferred by HDL against ischemic cardiovascular diseases has been most often attributed to its role in reverse cholesterol transport. However, HDLs exert divergent functions that include actions mediated by signalling via ...
Targeting arterial stiffening to prevent incident hypertension and associated organ damage. University of Antwerp
Investigation into mediators of central leptin sensitization upon acute exercise Ghent University
According to alarming reports of the World Health Organization, worldwide more people die
from the consequences of overfeeding than from hunger. Sedentary lifestyle and excess food
consumption have indeed provoked a worldwide obesity epidemic. Importantly, obesity is not
just a cosmetic problem, but predisposes to the development of chronic metabolic diseases,
including Type 2 diabetes (T2D) and ...