Causes of micro-inflammation and cardiovascular disease in chronic kidney disease: role of uremic peptides Ghent University
Retention of uremic solutes as well as renal replacement therapy contribute to micro-inflammation related to the cardial burden in chronic kidney disease. Especially the effect of uremic peptides on leukocytes and specific leukocyte subpopulations will be evaluated in an in vitro set-up. The pathophysiological mechanisms involved, will be elucidated, aiming at a classification of the retention solutes according to their toxicity.