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Recent advances in devices for vagus nerve stimulation Ghent University

Ann Mertens, Robrecht Raedt, Stefanie Gadeyne, Evelien Carrette, Paul Boon
Introduction: Vagus nerve stimulation (VNS) has become a valuable treatment option for refractory epilepsy and depression. To improve clinical efficacy and minimize side effects, novel device technology for VNS is under development and investigation.Areas covered: For epilepsy, the AspireSR (R), and SenTiva VNS therapy systems are the two most recently developed VNS devices. These novel devices have implemented a closed-loop approach and contain ...

Safe single-dose administration of propofol in patients with established Brugada syndrome: a retrospective database analysis University of Antwerp KU Leuven

Panagiotis Flamee, Carlo De Asmundis, Jigme T. Bhutia, Giulio Conte, Stefan Beckers, Vincent Umbrain, Christian Verborgh, Gian-Battista Chierchia, Sophie Van Malderen, Ruben Casado-Arroyo, et al.
BackgroundPropofol is an anesthetic drug with a very attractive pharmacokinetic profile, which makes it the induction agent of choice, especially in day-case surgery. Data on its potential proarrhythmic effects in patients with Brugada syndrome (BS) patients are still lacking. The aim of our study was to investigate whether a single dose of propofol triggered any adverse events in consecutive high-risk patients with BS. MethodsAll consecutive ...

Safe Single-Dose Administration of Propofol in Patients with Established Brugada Syndrome: A Retrospective Database Analysis. Vrije Universiteit Brussel

Panagiotis Flamée, Carlo de Asmundis, Jigme Tshering Bhutia, Giulio Conte, Stefan Beckers, Vincent Umbrain, Christian Verborgh, Gian Battista Chierchia, Sophie Van Malderen, Rubén Casado Arroyo, et al.
BACKGROUND:

Propofol is an anesthetic drug with a very attractive pharmacokinetic profile, which makes it the induction agent of choice, especially in day-case surgery. Data on its potential proarrhythmic effects in patients with Brugada syndrome (BS) patients are still lacking. The aim of our study was to investigate whether a single dose of propofol triggered any adverse events in consecutive high-risk patients with BS.
...

Outcomes From Patients With Multi-Vessel Disease Following Primary PCI: Staged PCI Imparts Very Low Mortality KU Leuven

Frans Van de Werf
BACKGROUND: CABG and PCI are effective means for revascularization of patients with multi-vessel coronary artery disease, but previous studies have not focused on treatment of patients that first undergo primary PCI. METHODS: Among patients enrolled in the global registry of acute coronary events (GRACE), clinical outcomes for patients presenting with STEMI treated with primary PCI were compared according to whether residual stenoses were ...

Timing van longslagaderklepvervanging in Tetralogie van Fallot KU Leuven

Bjorn Cools
Surgically corrected tetralogy of Fallot (TOF) patients with trans-annular patch frequently have an important pulmonary regurgitation (PR) resulting in chronic right ventricular volume overload, which has been proven to increase the risk for adverse outcomes. These patients require a valve replacement early versus late to avoid the development of life-threatening arrhythmias, heart failure and sudden cardiac death. There is, however, no ...

Late recovery of atrioventricular conduction after postsurgical chronic atrioventricular block is not exceptional KU Leuven

Rik Willems, Filip Rega, Marc Gewillig
OBJECTIVE: Postsurgical atrioventricular block may complicate surgery for congenital heart defects and is generally considered permanent when persisting longer than 14 days after surgery. In this study, we evaluate the occurrence of spontaneous late recovery of atrioventricular conduction in postsurgical chronic atrioventricular block and discuss its clinical implications. METHODS: We retrospectively reviewed all cardiac surgical procedures on ...

Position paper concerning the competence, performance and environment required in the practice of complex ablation procedures Vrije Universiteit Brussel

Philippe Maury, Pascal Defaye, Didier Klug, Christine Alonso, Frederic Anselme, Laurent Fauchier, Estelle Gandjbakhch, Daniel Gras, Jean Sylvain Hermida, Gabriel Laurent, et al.

The introduction of catheter ablation techniques has vastly improved the treatment of cardiac arrhythmias. However, as complex ablations are technically demanding and can cause various complications, they require a high level of expertise to maximize success rates and minimize complication rates. As French recommendations regarding the required technical competence and equipment are not yet available, this position paper has been compiled by ...

Stiff left atrial syndrome with pulmonary veins occlusion after percutaneous radiofrequency ablation Vrije Universiteit Brussel

Rani Jana L Kronenberger, Kaoru Tanaka, Carlo de Asmundis, Mark La Meir

BACKGROUND: Stiff left atrial syndrome (SLAS) and pulmonary vein (PV) occlusion are rare yet potentially major life-long complications after radiofrequency ablation for atrial fibrillation. While mostly controlled by medical management, SLAS can progress to refractory congestive heart failure. Treatment of PV stenosis and occlusion remains a challenging problem with ongoing risk for recurrence regardless of techniques employed. Herein we ...

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries Vrije Universiteit Brussel KU Leuven

Teeba Ibraheem Ahmad, A. Hoeft, P Holt, Rupert M Pearse
Background
As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care.

Methods
We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death ...

Should renin-angiotensin system inhibitors be stopped or not before non-cardiac surgery? Hasselt University

Sigrun Halvorsen, Pascal VRANCKX, Sean van Diepen
The global annual volume of major surgical procedures is estimated to exceed 300 million, representing ∼5% of the world's population, with numbers likely increasing due to an ageing population. 1 Approximately 85% of these are non-cardiac surgeries (NCSs). Perioperative mortality for patients over 45 years of age following NCS is around 2%, 2 with other complications, such as perioperative myocardial injury or infarction (PMIs), occurring much ...