Publications
Mixed adenoneuroendocrine carcinoma of the colon: molecular pathogenesis and treatment KU Leuven Ghent University
Neuroendocrine carcinoma in a patient with Birt-Hogg-Dube syndrome Ghent University
Whole-genome landscape of pancreatic neuroendocrine tumours Vrije Universiteit Brussel
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to more sensitive detection methods, and this increase is creating challenges for clinical management. We performed whole-genome sequencing of 102 primary PanNETs and defined the genomic events that characterize their pathogenesis. Here we describe the mutational signatures they harbour, including a deficiency in G:C > T:A base excision repair due to ...
Succinate Dehydrogenase (SDH)-Deficient Pancreatic Neuroendocrine Tumor Expands the SDH-Related Tumor Spectrum Vrije Universiteit Brussel
CONTEXT: Mutations in genes encoding the subunits of succinate dehydrogenase (SDH) can lead to pheochromocytoma/paraganglioma formation. However, SDH mutations have also been linked to nonparaganglionic tumors.
OBJECTIVE: The objective was to investigate which nonparaganglionic tumors belong to the SDH-associated tumor spectrum.
DESIGN: This was a retrospective cohort study.
SETTING: The setting was a tertiary referral ...