Publications
Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries; a multi-country population-based surveillance study Institute of Tropical Medicine University of Antwerp
Background In many countries, regular monitoring of the emergence of resistance to anti-tuberculosis drugs is hampered by the limitations of phenotypic testing for drug susceptibility. We therefore evaluated the use of genetic sequencing for surveillance of drug resistance in tuberculosis.
Methods Population-level surveys were done in hospitals and clinics in seven countries (Azerbaijan, Bangladesh, Belarus, Pakistan, Philippines, ...
Resistance to second-line anti-tuberculosis drugs among Peruvian multidrug resistant Mycobacterium tuberculosis strains Institute of Tropical Medicine
OBJECTIVES: To determine the drug resistance profiles for quinolones: ciprofloxacin (CFX), ofloxacin (OFX), moxifloxacin (MFX), and gatifloxacin (GFX); and for injectables: kanamycin (KAN), amikacin (AMK), and capreomycin (CAP) in multidrug resistant (MDR) strains. We also investigated the correlation between mutations in rrs, tlyA and gyrA/B genes, and the in vitro resistance to the second-line anti-tuberculosis drugs.
MATERIALS AND ...