High level of cross-resistance between kanamycin, amikacin, and capreomycin among Mycobacterium tuberculosis isolates from Georgia and a close relation with mutations in the rrs gene Institute of Tropical Medicine University of Antwerp
Impurity profiling of capreomycin using dual liquid chromatography coupled to mass spectrometry KU Leuven
Multicentre laboratory validation of the colorimetric redox indicator (CRI) assay for the rapid detection of extensively drug-resistant (XDR) Mycobacterium tuberculosis Institute of Tropical Medicine Ghent University
A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis Institute of Tropical Medicine
A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis is required to accelerate the development of rapid drug susceptibility testing methods based on genetic sequence.
Raw genotype-phenotype correlation data were extracted as part of a comprehensive systematic review to develop a standardised analytical approach for interpreting resistance associated mutations for rifampicin, isoniazid, ...
Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries; a multi-country population-based surveillance study Institute of Tropical Medicine University of Antwerp
Background In many countries, regular monitoring of the emergence of resistance to anti-tuberculosis drugs is hampered by the limitations of phenotypic testing for drug susceptibility. We therefore evaluated the use of genetic sequencing for surveillance of drug resistance in tuberculosis.
Methods Population-level surveys were done in hospitals and clinics in seven countries (Azerbaijan, Bangladesh, Belarus, Pakistan, Philippines, South ...
Sensitivity pattern of second line anti-tuberculosis drugs against clinical isolates of multidrug resistant Mycobacterium tuberculosis Ghent University
Resistance to second-line anti-tuberculosis drugs among Peruvian multidrug resistant Mycobacterium tuberculosis strains Institute of Tropical Medicine
OBJECTIVES: To determine the drug resistance profiles for quinolones: ciprofloxacin (CFX), ofloxacin (OFX), moxifloxacin (MFX), and gatifloxacin (GFX); and for injectables: kanamycin (KAN), amikacin (AMK), and capreomycin (CAP) in multidrug resistant (MDR) strains. We also investigated the correlation between mutations in rrs, tlyA and gyrA/B genes, and the in vitro resistance to the second-line anti-tuberculosis drugs.
MATERIALS AND ...