Development of a novel antiviral strategy directed against the nuclear import of HIV. KU Leuven
Insertion of the viral genome into host cell chromatin is a hallmark ofHuman Immunodeficiency Virus type 1 (HIV-1) replication. Catalyzed by the viral integrase (IN) enzyme, this step irreversibly links the fate ofthe provirus with that of the cell. IN however, has proved to be a tough nut for researchers to crack. Nevertheless, a number of milestone discoveries and insights accumulating over the last decade have propelled the field forward. ...