Aptamer micro-factories: replacing SELEX by a single-step aptamer selection strategy. KU Leuven
Aptamers are single stranded oligonucleotides that, similarly to antibodies, bind their targets with great affinity and specificity by adopting a defined 2D/3D structure. Aptamers have been widely employed as target recognition molecules in diagnostics and are currently being introduced in the clinic as therapeutics. Isolation of new aptamers is a non-trivial process relying on an in vitro method termed SELEX, based on the iterative ...