Harnessing lysosomal iron homeostasis to prevent melanoma dissemination KU Leuven
The capability of melanoma cells to reversibly (de)differentiate between cellular states following stress signals/drug treatments, represents a major obstacle to successful therapy. Although non-mutational mechanisms contribute to melanoma plasticity, their nature remains unresolved. In various cancers, iron homeostasis is aberrantly regulated to support key cancer cell hallmarks like metabolic plasticity and epigenetic regulation of ...