Validation of Actionable Genomic ABerrations in a paediatric Oncology Network for Doctorate students Ghent University
High-risk neuroblastoma (HR-NB) patients undergo intensive multi-modal treatment, with over half succumbing to their disease. HR-NB cells exhibit replicative stress, and targeting DNA damage response (DDR) pathways represents a viable therapeutic option. Pharmalogical CDK12 inactivation leads to downregulation of DDR genes, selectively reducing viability of NB cells. A novel zebrafish HR-NB xenograft model for high-throughput compound testing ...