Projects
LncRNAs as modulators of protein synthesis rewiring in cancer KU Leuven
An increasing body of evidence indicates that MYC and RAS-induced oncogenic signalling enhances protein synthesis in both the cytosol and mitochondria and that this increase is essential to cancer cell survival. Targeting translational rewiring may therefore offer novel therapeutic opportunities. However, given its essential role in normal cells, modulating translation in a cancer-cell specific manner remains a major challenge. LncRNA (Long ...
Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs). KU Leuven
Pilot project "population-based study into colorectal cancer". University of Antwerp
The role of the Protein Phosphatase 2A Activator PTPA in KRAS-mutant non-small-cell lung cancer development and treatment resistance KU Leuven
Reversible protein phosphorylation, catalyzed by kinases and phosphatases, is arguably one of the most prominent signaling mechanisms in the human cell. Protein Phosphatase 2A (PP2A) is a major family of Serine/Threonine protein phosphatases of which the members are involved in a broad array of cellular processes, such as mitogenic signaling, growth, cell division, DNA transcription, protein translation, DNA damage signaling and repair, ...
Implementation of population screening for breast, cervical end colorectal cancer - year 2023 Ghent University
A population-based screening is a systematic offer of screening to a population group with predetermined common characteristics. For example, it may involve women and/or men belonging to a certain age group. Population screening involves screening for a disease (e.g. breast cancer) or a precursor of a disease (e.g. colon polyps) or for a health risk (e.g. an unhealthy lifestyle), without any health complaints related to the disease, precursor ...
Operational implementation and quality assurance of the Flemish Breast Cancer Screening Programme. Ghent University
CPVOK (Centre for Prevention and Early Detection of Cancer), together with four similar centres, ensures the implementation and the quality assurance of the Flemish Breast Cancer Screening Programme. This screening programme is offered to the 50-69 years old female target population using the existing network of mammography units that are recognized for screening by the Flemish Government.
Understanding non-genetic processes remodelling the tumor ecosystem, cancer cell death and immune escape mechanisms KU Leuven
Efficient tumor clearance by anticancer therapies requires effective therapy-mediated debulking along with the engagement of the immune system. The induction of regulated cancer cell death (RCD) able to reinstate, rather than suppressing, anticancer immune responses -so called immunogenic cell death - is therefore a highly desirable therapeutic effect. However, the recognition and clearance of residual cancer cells by the immune system, ...