Projects
Cancer cells and their microenvironment: from gene regulatory networks to therapy Ghent University
It is now generally accepted that the tumor and its microenvironment (i.e., the stroma) cross-talk to each other at multiple levels to elicit carcinogenesis, invasion and progression to metastasis. In addition to the well-established stepwise accumulation of somatic genetic alterations in tumor cells, it has now become clear that genetic and (epi)genomic alterations that play an important role in the development and/or progression of (solid) ...
Human liver disease: study of the hepatic stem cells and their niche and development of novel model systems Ghent University
this project wishes to shed more light on the role of the hepatic stem cell in the genesis and evolution of a series of liver diseases such as liver cancer (hepatocellular carcinoma), liver cirrhosis, liver steatosis, and chronic infections of the liver caused by hepatitis B (HBV) and hepatitis C virus (HCV). In addition the IUAP consortium wishes to develop novel in vivo and in vitro models to studies these aforementioned liver diseases. ...
Determination of genetic and therapeutic dependencies of patient-derived models of brain cancer KU Leuven
Implementation of functional imaging and molecular diagnostics for patient-tailored treatment of prostate cancer. KU Leuven
Evidence-based medicine in cancer prevention at the University of Antwerp. University of Antwerp
Implementation of functional imaging and molecular diagnostics for patient-tailored treatment of prostate cancer. KU Leuven
Studying structure-function relationships in transferrin-artemisinin adducts by means of Raman optical activity. University of Antwerp
Analysis of protein/nucleic acid complexes by native ion mobility mass spectrometry. University of Antwerp
Signal transduction in inflammation: from gene to organism Ghent University
Inflammation is a physiological process that normally leads to recovery from injury by healing. However, if targeted destruction and assisted repair are not properly phased, inflammation can lead to persistent tissue damage by activated leukocytes, including reorganization of the extracellular matrix. Cytokines produced by the activated leukocytes trigger signal transduction cascades and positive feedback loops which will further lead to ...