InsP3 regulated calcium signaling microdomains in the physiology and pathophysiology of ventricular cardiomyocytes KU Leuven
Heart disease accounts for more than 40% of all death in Europe. It affects every third person in a world and remains the leading cause of mortality and morbidity. The current therapy based on antagonism of beta-adrenergic receptors, angiotensin converting enzyme and/or angiotensin type 2 receptors improves the outcome for people with heart failure. Nevertheless, the prevalence of heart failure continues to grow rapidly, highlighting the need ...