Exploring the role of intestinal cell metabolism and gastro-intestinal hormones in calcium homeostasis and pathology. KU Leuven
Adequate intestinal calcium absorption is essential to prevent bone loss caused by aging or pathologies. Calcium and vitamin D supplementations are therefore widely used, but this therapy is still confronted with issues of safety, compliance and limited efficacy. Using several transgenic mouse strains, we observed that vitamin D supplementation without adequate intestinal calcium transport has deleterious effects on bone. Novel therapeutic ...