Projects
The role of sclerostin in vascular calcification and the calcification paradox: necassary research for development of safe therapies to treat mineralization defects in bone and vessels. University of Antwerp
The calcification paradox: investigation into the mechanisms underlying the association between metabolic bone disease and vascular calcification. University of Antwerp
Nanoparticle-based targeted delivery of therapeutics against arterial media calcification, a major cardiovascular complication in elderly and patients with chronic kidney disease, diabetes and osteoporosis. University of Antwerp
Research network for Arterial Calcification University of Antwerp
Natural history and determinants of the burden of medial vascular calcification, using pseudoxanthoma elasticum as a model. Ghent University
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in Europe. This proposal addresses one of the hallmark changes in CVD and premature aging, namely medial vascular calcification (VCm). Considered a good target for diagnosis and prevention, a comprehensive understanding of the causes and consequences of VCm is lacking. We aim to contribute to this knowledge by studying a monogenic form of VCm, pseudoxanthoma elasticum ...
The role of androgens in chronic kidney desease: a missing link in the calcification paradox? KU Leuven
Androgens play an important role in the development and maintenance of the male reproductive system, the so-called classical target. However, they also have pleiotropic effects on other organs like bone and kidney. Although it is well established that androgen action is essential for normal bone mass accrual and maintenance in men, the contribution of specific AR effects either directly or indirectly mediated by the kidney is not fully ...