Projects
High-end molecular dynamics simulations combined with click chemistry synthesis to develop novel therapeutic compounds starting from small molecule fragments. University of Antwerp
Synthesis of novel types of macromolecular ligands using "click" chemistry: application for diverse Metal-calayzed reactions Ghent University
The aim of this research project is to develop novel types of ligand-containing polymer structures as a macromolecular support of a (copper)catalyst and to apply them for various metal-catalyzed reactions (e.g. ATRP polymerization). The synthesis of these novel macromolecular ligands will be "click" chemistry. Three types that will be investigated are: ligand-polymers, ligand-polymer beads and ligand-cryogels.
The development of an in vivo system for the site-specific modification of proteins with 'click' functionalized amino acids for biosensor applications Hasselt University
Exploration of novel 'click' and 'domino' reactions for the synthesis of tailor-made polymer architectures Ghent University
This project proposes the development of new domino reactions and their valorization. Initially, the focus will be on the in situ generation of thiols as starting materials for radical thiol-ene 'click' chemistry. Other domino approaches will be investigated and the synthesized products will be applied within the framework of current research projects.
Development and Application of modular UV triggered poylmer conjugation reactions Hasselt University
Membrane preparation via interfacial polymerization: development of ionic liquid based systems and advanced characterization tools KU Leuven
Synthesis of triazole analogues of Peloruside A via “click”-chemistry as potential antitumor compounds. Ghent University
The aim of this project is the synthesis of simplified analogues of Peloruside A. This should lead to a better understanding of the way of action and of which pharmacophoric groups are responsible for its antitumor activity. This should also result in analogues which are synthetically more easily accessible.
Synthesis and application of probes for serine and cysteine hydrolases and the polyamine transport system KU Leuven
Activity-based probes (ABPs) are small molecular tools that allow the detection and monitoring of enzyme activity by covalently binding onto the active site of the enzyme. They consist of a warhead that binds the enzyme, a recognition element that alters the selectivity of the probe and a detection tag that allows the visualization, quantification or purification of probe-labeled enzymes. ABPs are applied to elucidate enzyme function, enzyme ...