Development and validation of an assay to quantify anti-dsDNA antibody levels and avidity for more accurate diagnosis and monitoring of SLE KU Leuven
Systemic lupus erythematosus (SLE) is a heterogeneous and chronic multisystem autoimmune disease that mainly affects women between puberty and menopause. Typical in these patients is the presence of circulating anti-dsDNA and other anti-nuclear autoantibodies, which serve as serological markers for SLE diagnosis. Anti-dsDNA autoantibodies are the most important biomarkers as their concentration is directly linked to disease activity. The ...